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Overview

Ovulation Induction (OI)is a fertility treatment that uses medications to cause or regulate ovulation, or increase the number of eggs produced during a cycle, to increase the opportunity for pregnancy.

Some women may experience an excessive response by their ovaries to the fertility drugs. Ovarian hyperstimulation syndrome (OHSS) occurs in a minority of women who overrespond. Symptoms include severe discomfort, nausea, vomiting, abdominal distension and dehydration. It is important that the clinic is notified immediately if any of these symptoms occur during your treatment, as hospitalisation may be required.

Procedure

Ovulation Induction normally involves the following stages:

Stimulation

Ovulation Induction medications include clomiphene citrate. This oral drug promotes the growth of the fluid-filled sacks (follicles) containing the eggs. If you do not ovulate, or you ovulate and do not become pregnant after clomiphene therapy, other medications known as gonadotropins may be prescribed, either alone or in combination.

Egg release – ovulation

When the follicles are mature, usually between 16 and 20 millimetres in diameter depending on your stimulation medication, you will take an intramuscular injection of hCG in preparation for intercourse or intra-uterine insemination (IUI).

The potential fertility improvement that this type of treatment may yield depends on the woman’s age and diagnosis and the initial male semen analysis, and should be discussed with your specialist.

Gonadotropins are taken by injection under the skin. They replace natural follicle-stimulating hormone (FSH), and if they are successful the ovaries produce multiple follicles and high-quality, mature eggs.

Your hormone levels and follicular development are tracked throughout the stimulation cycle. If required, your medication protocol (the type and dose) may be altered for optimum results.

Who?

Ovulation Induction treatment is recommended for:

  • Women with unexplained infertility.
  • Women with long, irregular or infrequent cycles.
  • Women who are not spontaneously ovulating.
  • Couples with no male-factor infertility.

FAQ’s

The procedure is not painful as it is done under light sedation, but may cause mild discomfort. At our clinic, we use mild anesthesia administered through an IV route which relieves discomfort.

IVF is likely to be recommended for the following fertility problems:
1. If you have blocked or damaged fallopian tubes
2. If your partner has male infertility issues like Oligozoospermia, Teratozoospermia or Athenozoospermia.
3. If you have premature ovarian failure
4. If you have been trying to conceive for at least two years and a cause hasn’t been found to explain why you have not become pregnant.

1. Women with a tubal problem
2. Women with unexplained fertility
3. Women with severe endometriosis
4. Couples with male factor infertility

Before treatment start, you will discussmedical history and the treatment processincluding risk and side effects kith your doctor.
1. Stimulation- After your baseline scans, injections will stimulate your ovaries to develop multiple eggs
2. Monitoring- Regular scans and blood test allow us to monitor your ovanan response to the drug
3. Trigger injections- When hormones are at the right levels another injection will trigger the eggs to mature
4. Egg collection and sperm collection- Eggs are collected via a needle passed through the vagina whilst you are under sedation. A semen sample is required on the day of egg collection
5. Fertilization and embryo development- Eggs and sperm are placed P an incubator to fertilize. Embryo development is monitored by CRGH embryologist
6. Embryo transfer- The best ennbryo(s) 6 /are transferred back into the uterus. Any suitable embryo not transferred can be frozen for Later use
7. Pregnancy test- Patient takes a pregnancy test 16 days after embryo transfer. At this stage we will arrange appropriate support.

So the point is that the IVF success rate could vary based on the denominator used to calculate the IVF cycle outcome. Its always preferable to always define the success rate using all the available denominators and discuss every one of them with the couple. The couple should be able to understand the sucess chances for their particular condition. There are even more denominators like age, number of embryos transfered, frozen or fresh emebto transfer, ICSI, PGD / PGS tested embryos etc. This further gets complicated when each ivf clinic or ivf doctor in the center wants to boos their success rates to showcase themselves in this highly competitive era.