General
Embryo Arrest and Poor Embryo Quality
Embryos fail to develop beyond early cleavage or show fragmentation and arrest. Often reflects oocyte mitochondrial dysfunction or chromosomal abnormality.
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Overview
Overview
Embryos fail to develop beyond early cleavage or show fragmentation and arrest. Often reflects oocyte mitochondrial dysfunction or chromosomal abnormality.
Symptoms
Embryos stop dividing between day 2–5
High fragmentation rates
No blastocysts formed
Repeated across multiple cycles
Causes
1
Oocyte quality (mitochondrial dysfunction, aneuploidy)2
Maternal age3
Sperm DNA damage4
Genetic mutations (TUBB8, NLRP5)How It's Diagnosed
PGT-A
Sperm DNA fragmentation test
Time-lapse embryo morphokinetics
Female karyotype
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