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Iswarya Fertility Centre & Women's Hospital
Iswarya
Fertility Centre
Male Infertility

Klinefelter Syndrome (47,XXY)

The most common sex chromosome aneuploidy in males. Small testes, azoospermia, and low testosterone are the norm, but focal spermatogenesis allows sperm retrieval via mTESE in ~50% of cases.

Overview

Overview

The most common sex chromosome aneuploidy in males. Small testes, azoospermia, and low testosterone are the norm, but focal spermatogenesis allows sperm retrieval via mTESE in ~50% of cases.

Symptoms

Azoospermia
Small firm testes
Tall stature with long limbs
Gynaecomastia
Low testosterone

Causes

1
Non-disjunction during meiosis producing extra X chromosome

How It's Diagnosed

Karyotype (46,XXY confirmed)
FSH, LH (elevated)
Testosterone (low)
AMH (low)
Semen analysis

Take the First Step

Get a personalised treatment plan for Klinefelter Syndrome (47,XXY) from our fertility specialists

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