General
MTHFR Mutation and Fertility
MTHFR C677T and A1298C polymorphisms reduce folate metabolism efficiency. Associated with elevated homocysteine, recurrent pregnancy loss, and neural tube defect risk.
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Overview
Overview
MTHFR C677T and A1298C polymorphisms reduce folate metabolism efficiency. Associated with elevated homocysteine, recurrent pregnancy loss, and neural tube defect risk.
Symptoms
Recurrent miscarriage
Neural tube defects in offspring
Elevated homocysteine
Recurrent implantation failure
Causes
1
Autosomal genetic polymorphism2
Interacts with folate intake and other thrombophilic factorsHow It's Diagnosed
MTHFR gene mutation testing
Serum homocysteine
Folate and B12 levels
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