Female Infertility
Premature Ovarian Insufficiency (POI)
Loss of normal ovarian function before age 40, causing oestrogen deficiency and infertility. Spontaneous pregnancy is rare (5–10%).
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Overview
Overview
Loss of normal ovarian function before age 40, causing oestrogen deficiency and infertility. Spontaneous pregnancy is rare (5–10%).
Symptoms
Absent or irregular periods
Hot flushes
Night sweats
Vaginal dryness
Infertility
Causes
1
Autoimmune2
Fragile X premutation3
Turner mosaic4
Chemotherapy/radiation5
IdiopathicHow It's Diagnosed
FSH (elevated >25 IU/L on two tests 4+ weeks apart)
AMH (very low)
Karyotype
FMR1 testing
Autoimmune screen
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