Female Infertility
Premature Ovarian Reserve Decline
Low AMH and AFC in women under 35, years before expected menopause. Requires urgent fertility evaluation and possible egg banking.
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Overview
Overview
Low AMH and AFC in women under 35, years before expected menopause. Requires urgent fertility evaluation and possible egg banking.
Symptoms
Low AMH (<1 ng/mL under 35)
Low AFC (<5)
Irregular cycles starting
Family history of early menopause
Causes
1
Genetic (FMR1 premutation, BMP15 variants)2
Previous ovarian surgery3
Autoimmune4
Previous chemotherapy/radiationHow It's Diagnosed
AMH
AFC
Day 3 FSH
Karyotype
FMR1 testing
Autoimmune ovarian antibodies
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