General
Psychogenic Infertility and Stress
Chronic psychological stress activates the HPA axis, suppressing GnRH pulsatility and impairing ovulation and endometrial receptivity.
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Overview
Overview
Chronic psychological stress activates the HPA axis, suppressing GnRH pulsatility and impairing ovulation and endometrial receptivity.
Symptoms
Anovulation despite otherwise normal investigations
Irregular cycles during high-stress periods
Anxiety and depression
Causes
1
Hypothalamic-pituitary-adrenal axis over-activation2
Social and occupational stressorsHow It's Diagnosed
Exclude organic cause first
Psychological screening (PHQ-9, GAD-7)
Cortisol AM level
Hormone panel
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