Psychogenic Infertility and Stress

Chronic psychological stress activates the HPA axis, suppressing GnRH pulsatility and impairing ovulation and endometrial receptivity.

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Chronic psychological stress activates the HPA axis, suppressing GnRH pulsatility and impairing ovulation and endometrial receptivity.

Anovulation despite otherwise normal investigations

Irregular cycles during high-stress periods

Anxiety and depression

Hypothalamic-pituitary-adrenal axis over-activation

Social and occupational stressors

Exclude organic cause first

Psychological screening (PHQ-9, GAD-7)

Cortisol AM level

Hormone panel

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