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Iswarya Fertility Centre & Women's Hospital
Iswarya
Fertility Centre
Female Infertility

Recurrent Implantation Failure

Recurrent implantation failure (RIF) is when embryos repeatedly fail to implant during IVF, requiring specialised investigation and personalised treatment.

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Overview

What is Recurrent Implantation Failure?

Recurrent Implantation Failure (RIF) is generally defined as failure to achieve a clinical pregnancy after transferring at least 3–4 good-quality embryos over multiple IVF cycles. RIF is a complex condition involving embryo factors, uterine receptivity, and immune interactions.

Advanced Investigations at Iswarya Fertility

Our dedicated RIF clinic offers ERA (Endometrial Receptivity Array) to identify the personalised window of implantation, EMMA/ALICE tests for uterine microbiome assessment, PGT-A for chromosomally normal embryo selection, immunological workup (NK cells, thrombophilia panel), and hysteroscopy to assess the uterine cavity — developing a targeted protocol for each patient.

Symptoms

Failure to achieve pregnancy after 3 or more IVF embryo transfers
History of good-quality blastocysts that do not implant
Unexplained negative beta-hCG results
Abnormal uterine lining or cavity on investigation

Causes

1
Chromosomal abnormalities in embryos
2
Displaced window of implantation (ERA test abnormality)
3
Uterine abnormalities — fibroids, polyps, adhesions
4
Thrombophilia disorders reducing uterine blood flow
5
NK cell dysfunction causing immune rejection of embryo

How It's Diagnosed

ERA (Endometrial Receptivity Array) biopsy
EMMA and ALICE microbiome testing
PGT-A (Preimplantation Genetic Testing for Aneuploidy)
Hysteroscopy to inspect uterine cavity
Thrombophilia and NK cell immunological panel

Take the First Step

Get a personalised treatment plan for Recurrent Implantation Failure from our fertility specialists

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