Female Infertility
Thrombophilia and Recurrent Miscarriage
Inherited or acquired clotting disorders cause placental microthrombi, resulting in miscarriage or foetal growth restriction.
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Overview
Overview
Inherited or acquired clotting disorders cause placental microthrombi, resulting in miscarriage or foetal growth restriction.
Symptoms
Recurrent first- or second-trimester miscarriage
Previous DVT or PE
Family history of thrombosis
Causes
1
Factor V Leiden mutation2
Prothrombin gene mutation3
Protein C/S deficiency4
Antithrombin deficiencyHow It's Diagnosed
Factor V Leiden and prothrombin G20210A gene testing
Protein C, S, antithrombin levels
APS screen
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